Candidate gene expression and coding sequence variants in Warmblood horses with myofibrillar myopathy.

ABSTRACT:

Background

Myofibrillar myopathy (MFM) of unknown aetiology has recently been identified in Warmblood (WB) horses. In humans, 16 genes have been implicated in various MFM-like disorders.

Objectives

To identify variants in 16 MFM candidate genes and compare allele frequencies of all variants between MFM WB and non-MFM WB and coding variants with moderate or severe predicted effects in MFM WB with publicly available data of other breeds. To compare differential gene expression and muscle fibre contractile force between MFM and non-MFM WB.

Study design

Case-control.

Animals

8 MFM WB, 8 non-MFM WB, 33 other WB, 32 Thoroughbreds, 80 Quarter Horses and 77 horses of other breeds in public databases.

Methods

Variants were called within transcripts of 16 candidat

SUBMITTER: Williams ZJ 

PROVIDER: S-EPMC7864122 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature