ABSTRACT:

Background

Parkinson's disease (PD) is the second commonest neurodegenerative disease. The genetic basis of PD is indisputable. Both ADORA2A rs5760423 and CYP1A2 rs762551 have been linked to PD, to some extent, but the exact role of those polymorphisms in PD remains controversial.

Objective

We assessed the role of ADORA2A rs5760423 and CYP1A2 rs762551 on PD risk.

Methods

We genotyped 358 patients with PD and 358 healthy controls for ADORA2A rs5760423 and CYP1A2 rs762551. We also merged and meta-analyzed our data with data from previous studies, regarding these two polymorphisms and PD.

Results

No significant association with PD was revealed (p > 0.05), for either ADORA2A rs5760423 or CYP1A2 rs762551

SUBMITTER: Siokas V 

PROVIDER: S-EPMC7864159 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature