The Intersection of Mechanotransduction and Regenerative Osteogenic Materials.

ABSTRACT: Mechanical signals play a central role in cell fate determination and differentiation in both physiologic and pathologic circumstances. Such signals may be delivered using materials to generate discrete microenvironments for the purposes of tissue regeneration and have garnered increasing attention in recent years. Unlike the addition of progenitor cells or growth factors, delivery of a microenvironment is particularly attractive in that it may reduce the known untoward consequences of the former two strategies, such as excessive proliferation and potential malignant transformation. Additionally, the ability to spatially modulate the fabrication of materials allows for the creation of multiple microenvironments, particularly attractive for regenerating complex tissues. While many regenerat

SUBMITTER: Bertrand AA 

PROVIDER: S-EPMC7864218 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature