Differential expression of full-length and NH₂ terminally truncated FAM134B isoforms in normal physiology and cancer.

ABSTRACT: Selective autophagy of the endoplasmic reticulum (ER), namely ER-phagy, is mediated by ER-localized receptors, which are recognized and sequestered by GABARAP/LC3B-decorated phagophores and transferred to lysosomes for degradation. Being one such receptor, FAM134B plays critical roles in cellular processes such as protein quality control and neuronal survival. FAM134B has also been associated with different cancers, although its exact role remains elusive. We report here that the FAM134B gene encodes not one but at least two different protein isoforms: the full-length and the NH₂ terminally truncated forms. Their relative expression shows extreme variation, both within normal tissues and among cancer types. Expression of full-length FAM134B is restricted to

SUBMITTER: Keles U 

PROVIDER: S-EPMC7864244 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature