Relation between resting amygdalar activity and cardiovascular events: a longitudinal and cohort study.

ABSTRACT:

Background

Emotional stress is associated with increased risk of cardiovascular disease. We imaged the amygdala, a brain region involved in stress, to determine whether its resting metabolic activity predicts risk of subsequent cardiovascular events.

Methods

Individuals aged 30 years or older without known cardiovascular disease or active cancer disorders, who underwent ¹⁸F-fluorodexoyglucose PET/CT at Massachusetts General Hospital (Boston, MA, USA) between Jan 1, 2005, and Dec 31, 2008, were studied longitudinally. Amygdalar activity, bone-marrow activity, and arterial inflammation were assessed with validated methods. In a separate cross-sectional study we analysed the relation between perceived stress, amygdalar activity, arterial inflammation, and C-reactive

SUBMITTER: Tawakol A 

PROVIDER: S-EPMC7864285 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature