Analysis of TP53 gene and particular infrastructural alterations in invasive ductal mammary carcinoma.

ABSTRACT: This study was conducted in order to determine the mutational status of TP53 gene and to determine some particular aspects from ultrastructural level in invasive mammary ductal carcinoma. The cellular signaling pathway involving the TP53 gene acts in biological deoxyribonucleic acid (DNA) repair processes and cell cycle arrest following a signal transmitted to the p53 protein when posttranslational changes occur in the cell due to stress induced in the cell by both intrinsic and extrinsic factors. Cellular stress activates the transcription factor function of the protein that initiates, as the case may be, either DNA repair or programmed cell death (apoptosis). The TP53 gene is commonly mutated in many human cancers and also has a highly polymorphic grade. To determine the mutational statu

SUBMITTER: Mihalcea CE 

PROVIDER: S-EPMC7864295 | biostudies-literature | 2020 Apr-Jun

REPOSITORIES: biostudies-literature