The adverse effects of bisphosphonates in breast cancer: A systematic review and network meta-analysis.

ABSTRACT:

Background

Bisphosphonate drugs can be used to improve the outcomes of women with breast cancer. Whilst many meta-analyses have quantified their potential benefits for patients, attempts at comprehensive quantification of potential adverse effects have been limited. We undertook a meta-analysis with novel methodology to identify and quantify these adverse effects.

Methods

We systematically reviewed randomised controlled trials in breast cancer where at least one of the treatments was a bisphosphonate (zoledronic acid, ibandronate, pamidronate, alendronate or clodronate). Neoadjuvant, adjuvant and metastatic settings were examined. Primary outcomes were adverse events of any type or severity (excluding death). We carried out pairwise and network meta-analyses to estimate the

SUBMITTER: Jackson C 

PROVIDER: S-EPMC7864400 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature