Changes in the tumor microenvironment and outcome for TME-targeting therapy in glioblastoma: A pilot study.

ABSTRACT: Glioblastoma (GBM) is a hypervascular and aggressive primary malignant tumor of the central nervous system. Recent investigations showed that traditional therapies along with antiangiogenic therapies failed due to the development of post-therapy resistance and recurrence. Previous investigations showed that there were changes in the cellular and metabolic compositions in the tumor microenvironment (TME). It can be said that tumor cell-directed therapies are ineffective and rethinking is needed how to treat GBM. It is hypothesized that the composition of TME-associated cells will be different based on the therapy and therapeutic agents, and TME-targeting therapy will be better to decrease recurrence and improve survival. Therefore, the purpose of this study is to determine the changes in th

SUBMITTER: Ali S 

PROVIDER: S-EPMC7864405 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature