Procalcitonin, C-reactive protein, neutrophil gelatinase-associated lipocalin, resistin and the APTT waveform for the early diagnosis of serious bacterial infection and prediction of outcome in critically ill children.

ABSTRACT:

Objective

Bacterial Infections remains a leading cause of death in the Paediatric Intensive Care Unit (PICU). In this era of rising antimicrobial resistance, new tools are needed to guide antimicrobial use. The aim of this study was to investigate the accuracy of procalcitonin (PCT), neutrophil gelatinase-associated lipocalin (NGAL), resistin, activated partial thromboplastin time (aPTT) waveform and C-reactive protein (CRP) for the diagnosis of serious bacterial infection (SBI) in children on admission to PICU and their use as prognostic indicators.

Setting

A regional PICU in the United Kingdom.

Patients

Consecutive PICU admissions between October 2010 and June 2012.

Measurements

Blood samples were collected daily for biomarker measurement. The primary outcome

SUBMITTER: Nielsen MJ 

PROVIDER: S-EPMC7864456 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature