Risk factors for antimony treatment failure in American Cutaneous Leishmaniasis in Northwestern-Argentina.

ABSTRACT:

Background

To date, there is no specific literature available on the determinants for therapeutic failure (TF) with meglumine antimoniate (MA) in Northwestern-Argentina. This study aimed to identify epidemiological, clinical, and treatment-related factors that could be involved in TF.

Methodology/principal findings

We performed a case-control study. Cases were represented by patients who showed TF after administration of the first course of MA treatment, whereas, controls were determined as patients who evolved towards healing after the first MA cycle received. Crude Odds Ratios and their corresponding 90% confidence intervals (CI) were calculated, and risk factors were then tested by multivariate analysis using logistic binary regression. Three hundred and eighty-four patie

SUBMITTER: Garcia-Bustos MF 

PROVIDER: S-EPMC7864468 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature