Erucic Acid-Rich Yellow Mustard Oil Improves Insulin Resistance in KK-A^y Mice.

ABSTRACT: Obesity is a major risk factor for some metabolic disorders including type 2 diabetes. Enhancement of peroxisome proliferator-activated receptor (PPAR) γ, a master regulator of adipocyte differentiation, is known to increase insulin-sensitive small adipocytes. In contrast, decreased PPARγ activity is also reported to improve insulin resistance. We have previously identified erucic acid as a novel natural component suppressing PPARγ transcriptional activity. In this study, we investigated the effect of erucic acid-rich yellow mustard oil (YMO) on obese/diabetic KK-A^y mice. An in vitro luciferase reporter assay and mesenchymal stem cell (MSC) differentiation assay revealed that 25 µg/mL YMO significantly inhibited PPARγ transcriptional activity and differentiation of MSCs into adi

SUBMITTER: Takahashi A 

PROVIDER: S-EPMC7864507 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature