Excretable, ultrasmall hexagonal NaGdF₄:Yb50% nanoparticles for bimodal imaging and radiosensitization.

ABSTRACT:

Background

In this study, we report on the synthesis, imaging, and radiosensitizing properties of ultrasmall β-NaGdF₄:Yb50% nanoparticles as a multifunctional theranostic platform. The synthesized nanoparticles act as potent bimodal contrast agents with superior imaging properties compared to existing agents used for magnetic resonance imaging (MRI) and computed tomography (CT). Clonogenic assays demonstrated that these nanoparticles can act as effective radiosensitizers, provided that the nanoparticles are taken up intracellularly.

Results

Our ultrasmall β-NaGdF₄:Yb50% nanoparticles demonstrate improvement in T1-weighted contrast over the standard clinical MR imaging agent Gd-DTPA and similar CT signal enhancement capabilities as commercial agent iohex

SUBMITTER: Damasco JA 

PROVIDER: S-EPMC7864820 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature