Genetic Contribution to Non-alcoholic Fatty Liver Disease and Prognostic Implications.

ABSTRACT:

Purpose of review

Non-alcoholic fatty liver disease (NAFLD) is a major and increasing health burden, with the potential to overwhelm hepatology services. However, only a minority of patients develop advanced liver disease. The challenge is early identification of patients at risk of progression. This review aims to summarize current knowledge on the genetic predisposition to NAFLD, and its implications for prognostication and risk stratification.

Recent findings

PNPLA3-I148M is the most robustly associated genetic variant with NAFLD. Recently, variants in TM6SF2, MBOAT7, GCKR and HSD17B13 have also been implicated. NAFLD is a complex disease, and any one genetic variant alone is insufficient for risk stratification, but combining multiple genetic variants with other paramete

SUBMITTER: Martin K 

PROVIDER: S-EPMC7864835 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature