Co-expression of intermediate filaments glial fibrillary acidic protein and cytokeratin in pituitary adenoma.

ABSTRACT:

Purpose

To analyze the co-expression of the intermediate filaments GFAP and cytokeratin in 326 pituitary adenomas with regard to the distribution pattern, the subtype of the adenoma and clinical prognostic data.

Methods

Tissue from 326 pituitary adenomas and 13 normal anterior pituitaries collected in the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, between 2006 and 2009 was investigated by immunohistochemistry, immunofluorescence and electron microscopy.

Results

Co-expression of intermediate filaments GFAP and cytokeratin was associated with hormone expression in 62/278 cases (22%), but only found in 2/48 (4%) of null cell adenomas (p < 0.01). Simultaneous co-expression of GFAP and cytokeratin in the same cells was demonstrated in 26 out

SUBMITTER: Wiesnagrotzki N 

PROVIDER: S-EPMC7864846 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature