Inflammation and fibrosis in Crohn's disease: location-matched histological correlation of small bowel ultrasound features.

ABSTRACT:

Purpose

To evaluate the utility of mural and extramural sonographic features of Crohn's Disease as potential imaging biomarkers of inflammation and fibrosis against whole-mount histological sections.

Methods

Twelve Crohn's disease patients (Mean age 35(25-69), 7 males) underwent small bowel ultrasound prior to small bowel resection. Two radiologists in consensus graded multiple parameters including mural, mucosal and submucosal thickness, submucosal/mesenteric echogenicity and clarity and mural Doppler signal in 50 selected bowel cross-sections. Matching with histological sampling sites was facilitated via scanning of the resected specimen. A histopathologist scored acute and chronic inflammation, and fibrosis (using histological scoring systems) following analysis of whole

SUBMITTER: Bhatnagar G 

PROVIDER: S-EPMC7864849 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature