Bidirectional perisomatic inhibitory plasticity of a Fos neuronal network.

ABSTRACT: Behavioural experiences activate the FOS transcription factor in sparse populations of neurons that are critical for encoding and recalling specific events^1-3. However, there is limited understanding of the mechanisms by which experience drives circuit reorganization to establish a network of Fos-activated cells. It is also not known whether FOS is required in this process beyond serving as a marker of recent neural activity and, if so, which of its many gene targets underlie circuit reorganization. Here we demonstrate that when mice engage in spatial exploration of novel environments, perisomatic inhibition of Fos-activated hippocampal CA1 pyramidal neurons by parvalbumin-expressing interneurons is enhanced, whereas perisomatic inhibition by cholecystokinin-expressing interneur

SUBMITTER: Yap EL 

PROVIDER: S-EPMC7864877 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature