Control of osteoblast regeneration by a train of Erk activity waves.

ABSTRACT: Regeneration is a complex chain of events that restores a tissue to its original size and shape. The tissue-wide coordination of cellular dynamics that is needed for proper morphogenesis is challenged by the large dimensions of regenerating body parts. Feedback mechanisms in biochemical pathways can provide effective communication across great distances^1-5, but how they might regulate growth during tissue regeneration is unresolved^6,7. Here we report that rhythmic travelling waves of Erk activity control the growth of bone in time and space in regenerating zebrafish scales, millimetre-sized discs of protective body armour. We find that waves of Erk activity travel across the osteoblast population as expanding concentric rings that are broadcast from a central source,

SUBMITTER: De Simone A 

PROVIDER: S-EPMC7864885 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature