Cell-Extracellular Matrix Interactions Play Multiple Essential Roles in Aortic Arch Development.

ABSTRACT:

Rationale

Defects in the morphogenesis of the fourth pharyngeal arch arteries (PAAs) give rise to lethal birth defects. Understanding genes and mechanisms regulating PAA formation will provide important insights into the etiology and treatments for congenital heart disease.

Objective

Cell-ECM (extracellular matrix) interactions play essential roles in the morphogenesis of PAAs and their derivatives, the aortic arch artery and its major branches; however, their specific functions are not well-understood. Previously, we demonstrated that integrin α5β1 and Fn1 (fibronectin) expressed in the Isl1 lineages regulate PAA formation. The objective of the current studies was to investigate cellular mechanisms by which integrin α5β1 and Fn1 regulate aortic arch artery morphogene

SUBMITTER: Warkala M 

PROVIDER: S-EPMC7864893 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature