Histamine H₃ Receptor Function Biases Excitatory Gain in the Nucleus Accumbens.

ABSTRACT:

Background

Histamine (HA), a wake-promoting monoamine implicated in stress-related arousal states, is synthesized in histidine decarboxylase-expressing hypothalamic neurons of the tuberomammillary nucleus. Histidine decarboxylase-containing varicosities diffusely innervate striatal and mesolimbic networks, including the nucleus accumbens (NAc). The NAc integrates diverse monoaminergic inputs to coordinate motivated behavior. While the NAc expresses various HA receptor subtypes, mechanisms by which HA modulates NAc circuit dynamics are undefined.

Methods

Using male D1tdTomato transgenic reporter mice, whole-cell patch-clamp electrophysiology, and input-specific optogenetics, we employed a targeted pharmacological approach to interrogate synaptic mechanisms recruited by HA sig

SUBMITTER: Manz KM 

PROVIDER: S-EPMC7865000 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature