Clinical, molecular, metabolic, and immune features associated with oxidative phosphorylation in melanoma brain metastases.

ABSTRACT:

Background

Recently, we showed that melanoma brain metastases (MBMs) are characterized by increased utilization of the oxidative phosphorylation (OXPHOS) metabolic pathway compared to melanoma extracranial metastases (ECMs). MBM growth was inhibited by a potent direct OXPHOS inhibitor, but observed toxicities support the need to identify alternative therapeutic strategies. Thus, we explored the features associated with OXPHOS to improve our understanding of the pathogenesis and potential therapeutic vulnerabilities of MBMs.

Methods

We applied an OXPHOS gene signature to our cohort of surgically resected MBMs that had undergone RNA-sequencing (RNA-seq) (n = 88). Clustering by curated gene sets identified MBMs with significant enrichment (High-OXPHOS; n = 21) and

SUBMITTER: Fischer GM 

PROVIDER: S-EPMC7865080 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature