Implications of liver injury in risk-stratification and management of patients with COVID-19.

ABSTRACT:

Background

Infection with SARS-CoV-2 has been associated with liver dysfunction, aggravation of liver burden, and liver injury. This study aimed to assess the effects of liver injuries on the clinical outcomes of patients with COVID-19.

Methods

A total of 1520 patients with severe or critical COVID-19 from Huoshenshan Hospital, Wuhan, were enrolled. Chronic liver disease (CLD) was confirmed by consensus diagnostic criteria. Laboratory test results were compared between different groups. scRNA-seq data and bulk gene expression profiles were used to identify cell types associated with liver injury.

Results

A total of 10.98% of patients with severe or critical COVID-19 developed liver injury after admission that was associated with significantly higher rates of mortality

SUBMITTER: Shao J 

PROVIDER: S-EPMC7865118 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature