Concordance of Immune-Related Markers in Lymphocytes and Prefrontal Cortex in Schizophrenia.

ABSTRACT: Schizophrenia is a severe neuropsychiatric disorder associated with a wide array of transcriptomic and neurobiochemical changes. Genome-wide transcriptomic profiling conducted in postmortem brain have provided novel insights into the pathophysiology of this disorder, and identified biological processes including immune/inflammatory-related responses, metabolic, endocrine, and synaptic function. However, few studies have investigated whether similar changes are present in peripheral tissue. Here, we used RNA-sequencing to characterize transcriptomic profiles of lymphocytes in 18 nonpsychotic controls and 19 individuals with schizophrenia. We identified 2819 differentially expressed transcripts (P _nominal < .05) in the schizophrenia group when compared to controls. Bioinfor

SUBMITTER: Gatta E 

PROVIDER: S-EPMC7865130 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature