Genomic evolution of antibiotic resistance is contingent on genetic background following a long-term experiment with Escherichia coli.

ABSTRACT: Antibiotic resistance is a growing health concern. Efforts to control resistance would benefit from an improved ability to forecast when and how it will evolve. Epistatic interactions between mutations can promote divergent evolutionary trajectories, which complicates our ability to predict evolution. We recently showed that differences between genetic backgrounds can lead to idiosyncratic responses in the evolvability of phenotypic resistance, even among closely related Escherichia coli strains. In this study, we examined whether a strain's genetic background also influences the genotypic evolution of resistance. Do lineages founded by different genotypes take parallel or divergent mutational paths to achieve their evolved resistance states? We addressed this question by sequencing

SUBMITTER: Card KJ 

PROVIDER: S-EPMC7865137 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature