DNA methylation-linked chromatin accessibility affects genomic architecture in Arabidopsis.

ABSTRACT: DNA methylation is a major epigenetic modification found across species and has a profound impact on many biological processes. However, its influence on chromatin accessibility and higher-order genome organization remains unclear, particularly in plants. Here, we present genome-wide chromatin accessibility profiles of 18 Arabidopsis mutants that are deficient in CG, CHG, or CHH DNA methylation. We find that DNA methylation in all three sequence contexts impacts chromatin accessibility in heterochromatin. Many chromatin regions maintain inaccessibility when DNA methylation is lost in only one or two sequence contexts, and signatures of accessibility are particularly affected when DNA methylation is reduced in all contexts, suggesting an interplay between different types of DNA methy

SUBMITTER: Zhong Z 

PROVIDER: S-EPMC7865151 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature