Transcriptome Patterns of BRCA1- and BRCA2- Mutated Breast and Ovarian Cancers.

ABSTRACT: Mutations in the BRCA1 and BRCA2 genes are known risk factors and drivers of breast and ovarian cancers. So far, few studies have been focused on understanding the differences in transcriptome and functional landscapes associated with the disease (breast vs. ovarian cancers), gene (BRCA1 vs. BRCA2), and mutation type (germline vs. somatic). In this study, we were aimed at systemic evaluation of the association of BRCA1 and BRCA2 germline and somatic mutations with gene expression, disease clinical features, outcome, and treatment. We performed BRCA1/2 mutation centered RNA-seq data analysis of breast and ovarian cancers from the TCGA repository using transcriptome and phenotype "portrayal" with multi-layer self-organizing maps and functional

SUBMITTER: Arakelyan A 

PROVIDER: S-EPMC7865215 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature