Bovine Milk-Derived Exosomes as a Drug Delivery Vehicle for miRNA-Based Therapy.

ABSTRACT: MicroRNAs (miRNAs) are small non-coding RNAs with a known role as mediators of gene expression in crucial biological processes, which converts them into high potential contenders in the ongoing search for effective therapeutic strategies. However, extracellular RNAs are unstable and rapidly degraded, reducing the possibility of successfully exerting a biological function in distant target cells. Strategies aimed at enhancing the therapeutic potential of miRNAs include the development of efficient, tissue-specific and nonimmunogenic delivery methods. Since miRNAs were discovered to be naturally transported within exosomes, a type of extracellular vesicle that confers protection against RNase degradation and increases miRNA stability have been proposed as ideal delivery vehicles for miRNA-ba

SUBMITTER: Del Pozo-Acebo L 

PROVIDER: S-EPMC7865385 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature