Quantification of Immune Variables from Liquid Biopsy in Breast Cancer Patients Links Vδ2⁺ γδ T Cell Alterations with Lymph Node Invasion.

ABSTRACT: The rationale for therapeutic targeting of Vδ2⁺ γδ T cells in breast cancer is strongly supported by in vitro and murine preclinical investigations, characterizing them as potent breast tumor cell killers and source of Th1-related cytokines, backing cytotoxic αβ T cells. Nonetheless, insights regarding Vδ2⁺ γδ T cell phenotypic alterations in human breast cancers are still lacking. This paucity of information is partly due to the challenging scarcity of these cells in surgical specimens. αβ T cell phenotypic alterations occurring in the tumor bed are detectable in the periphery and correlate with adverse clinical outcomes. Thus, we sought to determine through an exploratory study whether Vδ2⁺ γδ T cells phenotypic changes can be detected within breast cance

SUBMITTER: Fattori S 

PROVIDER: S-EPMC7865589 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature