Glutamine Uptake via SNAT6 and Caveolin Regulates Glutamine-Glutamate Cycle.

ABSTRACT: SLC38A6 (SNAT6) is the only known member of the SLC38 family that is expressed exclusively in the excitatory neurons of the brain. It has been described as an orphan transporter with an unknown substrate profile, therefore very little is known about SNAT6. In this study, we addressed the substrate specificity, mechanisms for internalization of SNAT6, and the regulatory role of SNAT6 with specific insights into the glutamate-glutamine cycle. We used tritium-labeled amino acids in order to demonstrate that SNAT6 is functioning as a glutamine and glutamate transporter. SNAT6 revealed seven predicted transmembrane segments in a homology model and was localized to caveolin rich sites at the plasma membrane. SNAT6 has high degree of specificity for glutamine and glutamate. Presence of these subs

SUBMITTER: Gandasi NR 

PROVIDER: S-EPMC7865731 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature