Eighty Years of Targeting Androgen Receptor Activity in Prostate Cancer: The Fight Goes on.

ABSTRACT: Prostate cancer (PCa) is the most common cancer in men in the West, other than skin cancer, accounting for over a quarter of cancer diagnoses in US men. In a seminal paper from 1941, Huggins and Hodges demonstrated that prostate tumours and metastatic disease were sensitive to the presence or absence of androgenic hormones. The first hormonal therapy for PCa was thus castration. In the subsequent eighty years, targeting the androgen signalling axis, where possible using drugs rather than surgery, has been a mainstay in the treatment of advanced and metastatic disease. Androgens signal via the androgen receptor, a ligand-activated transcription factor, which is the direct target of many such drugs. In this review we discuss the role of the androgen receptor in PCa and how the combination of

SUBMITTER: Estebanez-Perpina E 

PROVIDER: S-EPMC7865914 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature