Post-Translational Modifications of the Energy Guardian AMP-Activated Protein Kinase.

ABSTRACT: Physical exercise elicits physiological metabolic perturbations such as energetic and oxidative stress; however, a diverse range of cellular processes are stimulated in response to combat these challenges and maintain cellular energy homeostasis. AMP-activated protein kinase (AMPK) is a highly conserved enzyme that acts as a metabolic fuel sensor and is central to this adaptive response to exercise. The complexity of AMPK's role in modulating a range of cellular signalling cascades is well documented, yet aside from its well-characterised regulation by activation loop phosphorylation, AMPK is further subject to a multitude of additional regulatory stimuli. Therefore, in this review we comprehensively outline current knowledge around the post-translational modifications of AMPK, including n

SUBMITTER: Ovens AJ 

PROVIDER: S-EPMC7866021 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature