Clinical and Molecular-Based Approach in the Evaluation of Hepatocellular Carcinoma Recurrence after Radical Liver Resection.

ABSTRACT:

Background

Hepatic resection remains the treatment of choice for patients with early-stage HCC with preserved liver function. Unfortunately, however, the majority of patients develop tumor recurrence. While several clinical factors were found to be associated with tumor recurrence, HCC pathogenesis is a complex process of accumulation of somatic genomic alterations, which leads to a huge molecular heterogeneity that has not been completely understood. The aim of this study is to complement potentially predictive clinical and pathological factors with next-generation sequencing genomic profiling and loss of heterozygosity analysis.

Methods

124 HCC patients, who underwent a primary hepatic resection from January 2016 to December 2019, were recruited for this study. Next-genera

SUBMITTER: Gruttadauria S 

PROVIDER: S-EPMC7866287 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature