Gender-specific associations between polymorphisms of the circadian gene RORA and cutaneous melanoma susceptibility.

ABSTRACT:

Background

Melanoma is the deadliest of skin cancers and has an increasing annual incidence worldwide. It is a multi-factorial disease most likely arising from both genetic predisposition and environmental exposure to ultraviolet light. Genetic variability of the components of the biological circadian clock is recognized to be a risk factor for different type of cancers. Moreover, two variants of a clock gene, RORA, have been associated with melanoma patient's prognosis. Our aim is to test the hypothesis that specific single nucleotide polymorphisms (SNPs) of the circadian clock genes may significantly influence the predisposition to develop cutaneous melanoma or the outcome of melanoma patients.

Methods

We genotyped 1239 subjects, 629 cases of melanoma and 610 healthy contr

SUBMITTER: Benna C 

PROVIDER: S-EPMC7866430 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature