Nocturnal Hypoxemia and CT Determined Pulmonary Artery Enlargement in Smokers.

ABSTRACT:

Background

Pulmonary artery enlargement (PAE) detected using chest computed tomography (CT) is associated with poor outcomes in chronic obstructive pulmonary disease (COPD). It is unknown whether nocturnal hypoxemia occurring in smokers, with or without COPD, obstructive sleep apnoea (OSA) or their overlap, may be associated with PAE assessed by chest CT.

Methods

We analysed data from two prospective cohort studies that enrolled 284 smokers in lung cancer screening programs and completing baseline home sleep studies and chest CT scans. Main pulmonary artery diameter (PAD) and the ratio of the PAD to that of the aorta (PA:Ao ratio) were measured. PAE was defined as a PAD ≥ 29 mm in men and ≥27 mm in women or as a PA:Ao ratio > 0.9. We evaluated the association of PAE with bas

SUBMITTER: Marin-Oto M 

PROVIDER: S-EPMC7866508 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature