Safety of high-dose Puerariae Lobatae Radix in adolescent rats based on metabolomics.

ABSTRACT: Puerariae Lobatae Radix (PLR) is the dried root of the leguminous plant Pueraria lobata and is a common component of health products and medicines. Although it is considered safe, some studies have reported that PLR has hepatotoxicity and estrogen-like effects. In this study, the safety of high doses of PLR water extract administered to adolescent SD rats for 30 days was evaluated by biochemical, histopathological, and metabolomic analyses. Overall, there were no significant differences between the low-dose and blank control groups in parameter values, including organ wet weight, organ coefficient, routine blood indicators, serum biochemical indexes of liver and renal function, levels of estradiol and testosterone, histopathological parameters, and primar

SUBMITTER: Chen L 

PROVIDER: S-EPMC7866568 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature