Novel immune-related genes in the tumor microenvironment with prognostic value in breast cancer.

ABSTRACT:

Background

Breast cancer is one of the most frequently diagnosed cancers among women worldwide. Alterations in the tumor microenvironment (TME) have been increasingly recognized as key in the development and progression of breast cancer in recent years. To deeply comprehend the gene expression profiling of the TME and identify immunological targets, as well as determine the relationship between gene expression and different prognoses is highly critical.

Methods

The stromal/immune scores of breast cancer patients from The Cancer Genome Atlas (TCGA) were employed to comprehensively evaluate the TME. Then, TME characteristics were assessed, overlapping genes of the top 3 Gene Ontology (GO) terms and upregulated differentially expressed genes (DEGs) were analyzed. Finally, throu

SUBMITTER: Tan W 

PROVIDER: S-EPMC7866632 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature