Identification of S1PR3 gene signature involved in survival of sepsis patients.

ABSTRACT:

Background

Sepsis is a life-threatening complication of infection that rapidly triggers tissue damage in multiple organ systems and leads to multi-organ deterioration. Up to date, prognostic biomarkers still have limitations in predicting the survival of patients with sepsis. We need to discover more prognostic biomarkers to improve the sensitivity and specificity of the prognosis of sepsis patients. Sphingosine-1-phosphate (S1P) receptor 3 (S1PR3), as one of the S1P receptors, is a prospective prognostic biomarker regulating sepsis-relevant events, including compromised vascular integrity, antigen presentation, and cytokine secretion. Until now, no S1PR3-related prognostic gene signatures for sepsis patients have been found.

Methods

This study intends to obtain an S1PR3-ass

SUBMITTER: Feng A 

PROVIDER: S-EPMC7866676 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature