Adults with Prader-Willi syndrome exhibit a unique microbiota profile.

ABSTRACT:

Objective

Adults with Prader-Willi syndrome (PWS) require less energy intake to maintain body weight than the general adult population. This, combined with their altered gastrointestinal transit time, may impact microbiota composition. The aim of the study was to determine if the fecal microbiota composition of adults with PWS differed from non-affected adults. Using usual diet/non-interventional samples, fecal microbiota composition was analyzed using 16S rRNA gene amplicon sequencing and data from adults with PWS were merged with four other adult cohorts that differed by geographical location and age. QIIME 2™ sample-classifier, machine learning algorithms were used to cross-train the samples and predict from which dataset the taxonomic profiles belong. Taxa that most distinguish

SUBMITTER: Dahl WJ 

PROVIDER: S-EPMC7866703 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature