The expression characteristics and prognostic roles of autophagy-related genes in gastric cancer.

ABSTRACT:

Background

Autophagy is an evolutionally highly conserved process, accompanied by the dynamic changes of various molecules, which is necessary for the orderly degradation and recycling of cellular components. The aim of the study was to identify the role of autophagy-related (ATG) genes in the occurrence and development of gastric cancer (GC).

Methods

Data from Oncomine dataset was used for the differential expression analysis between cancer and normal tissues. The association of ATG genes expression with clinicopathologic indicators was evaluated by The Cancer Genome Atlas (TCGA) database and Gene Expression Omnibus (GEO) database. Moreover, using the TCGA datasets, the prognostic role of ATG genes was assessed. A nomogram was further built to assess th

SUBMITTER: Wang M 

PROVIDER: S-EPMC7866901 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature