Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood.

ABSTRACT: Epidemiology studies suggested that low birthweight was associated with a higher risk of hypertension in later life. However, little is known about the causality of such associations. In our study, we evaluated the causal association of low birthweight with adulthood hypertension following a standard analytic protocol using the study-level data of 183,433 participants from 60 studies (CHARGE-BIG consortium), as well as that with blood pressure using publicly available summary-level genome-wide association data from EGG consortium of 153,781 participants, ICBP consortium and UK Biobank cohort together of 757,601 participants. We used seven SNPs as the instrumental variable in the study-level analysis and 47 SNPs in the summary-level analysis. In the study-level analyses, decreased birthweig

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC7867117 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature