Targeting Oncoimmune Drivers of Cancer Metastasis.

ABSTRACT: Residual metastasis is a major cause of cancer-associated death. Recent advances in understanding the molecular basis of the epithelial-mesenchymal transition (EMT) and the related cancer stem cells (CSCs) have revealed the landscapes of cancer metastasis and are promising contributions to clinical treatments. However, this rarely leads to practical advances in the management of cancer in clinical settings, and thus cancer metastasis is still a threat to patients. The reason for this may be the heterogeneity and complexity caused by the evolutional transformation of tumor cells through interactions with the host environment, which is composed of numerous components, including stromal cells, vascular cells, and immune cells. The reciprocal evolution further raises the possibility of success

SUBMITTER: Kudo-Saito C 

PROVIDER: S-EPMC7867187 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature