The Role of BRCA1/2-Mutated Tumor Microenvironment in Breast Cancer.

ABSTRACT: Taking into account the factors of high incidence rate, prevalence and mortality, breast cancer represents a crucial social and economic burden. Most cases of breast cancer develop as a consequence of somatic mutations accumulating in mammary epithelial cells throughout lifetime and approximately 5-10% can be ascribed to monogenic predispositions. Even though the role of genetic predispositions in breast cancer is well described in the context of genetics, very little is known about the role of the microenvironment carrying the same aberrant cells impaired by the germline mutation in the breast cancer development and progression. Based on the clinical observations, carcinomas carrying mutations in hereditary tumor-suppressor genes involved in maintaining genome integrity such as BRCA1/2

SUBMITTER: Miklikova S 

PROVIDER: S-EPMC7867315 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature