Comparative Analysis Identifies Similarities between the Human and Murine Microglial Sensomes.

ABSTRACT: One of the essential functions of microglia is to continuously sense changes in their environment and adapt to those changes. For this purpose, they use a set of genes termed the sensome. This sensome is comprised of the most abundantly expressed receptors on the surface of microglia. In this study, we updated previously identified mouse microglial sensome by incorporating an additional published RNAseq dataset into the data-analysis pipeline. We also identified members of the human microglial sensome using two independent human microglia RNAseq data sources. Using both the mouse and human microglia sensomes, we identified a key set of genes conserved between the mouse and human microglial sensomes as well as some differences between the species. We found a key set of 57 genes to be conser

SUBMITTER: Abels ER 

PROVIDER: S-EPMC7867338 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature