From Liver Cirrhosis to Cancer: The Role of Micro-RNAs in Hepatocarcinogenesis.

ABSTRACT: In almost all cases, hepatocellular carcinoma (HCC) develops as the endpoint of a sequence that starts with chronic liver injury, progresses to liver cirrhosis, and finally, over years and decades, results in liver cancer. Recently, the role of non-coding RNA such as microRNA (miRNA) has been demonstrated in the context of chronic liver diseases and HCC. Moreover, data from a phase II trial suggested a potential role of microRNAs as therapeutics in hepatitis-C-virus infection, representing a significant risk factor for development of liver cirrhosis and HCC. Despite progress in the clinical management of chronic liver diseases, pharmacological treatment options for patients with liver cirrhosis and/or advanced HCC are still limited. With their potential to regulate whole networks of genes,

SUBMITTER: Mohr R 

PROVIDER: S-EPMC7867354 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature