VDR Gene Polymorphisms in Healthy Individuals with Family History of Premature Coronary Artery Disease.

ABSTRACT:

Aim

The gene encoding the vitamin D receptor (VDR) is considered in many studies to be a good candidate responsible for susceptibility to several diseases such as coronary artery disease (CAD). Epidemiological data show that cardiovascular disease is one of the major health problems in Polish society. Basic studies show that genetic factors play a significant role in the pathogenesis of CAD. We conducted this clinical study to determine if the VDR gene polymorphisms TaqI (rs731236), ApaI (rs7975232), and FokI (rs2228570) could predispose healthy individuals to an increased risk of premature CAD (P-CAD) incidents.

Methods

We genotyped 845 subjects in a cohort consisting of 386 healthy volunteers with a documented P-CAD incident in their first-degree relatives an

SUBMITTER: Fronczek M 

PROVIDER: S-EPMC7867440 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature