NR3C2-Related Transcriptome Profile and Clinical Outcome in Invasive Breast Carcinoma.

ABSTRACT:

Background

Increasing evidence has indicated that the nuclear receptor subfamily 3 group C member 2 (NR3C2) may be associated with tumorigenesis and patient prognosis for certain types of tumors. However, the clinical significance of NR3C2 is unclear in invasive breast carcinoma (BRCA).

Methods

We used bioinformatics to broadly investigate and obtain a deeper understanding of the prognostic significance between NR3C2 and BRCA. RNA-sequencing data and clinical information of patients with BRCA from the Cancer Genome Atlas database were collected for subsequent analysis. The diagnostic efficacy of NR3C2 was evaluated by calculating the receiver operating characteristic curve. The prognostic value of NR3C2 was evaluated by Kaplan-Meier analysis and Cox regression analysis for p

SUBMITTER: Lu J 

PROVIDER: S-EPMC7867450 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature