The prognostic significance of interferon-stimulated gene 15 (ISG15) in invasive breast cancer.

ABSTRACT:

Background

Lymphovascular invasion (LVI) is a prognostic factor in early-stage invasive breast cancer (BC). Through bioinformatics, data analyses of multiple BC cohorts revealed the positive association between interferon-stimulated gene 15 (ISG15) LVI status. Thus, we explored the prognostic significance of ISG15 in BC.

Methods

The prognostic significance of ISG15 mRNA was assessed in METABRIC (n = 1980), TCGA (n = 854) and Kaplan-Meier Plotter (n = 3951). ISG15 protein was evaluated using immunohistochemistry (n = 859) in early-stage invasive BC patients with long-term follow-up. The associations between ISG15 expression and clinicopathological features, expression of immune cell markers and patient outcome data were evaluated.

Results

High mRNA and protein ISG15 ex

SUBMITTER: Kariri YA 

PROVIDER: S-EPMC7867506 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature