The association of GATM polymorphism with statin-induced myopathy: a systematic review and meta-analysis.

ABSTRACT:

Purpose

Statin-induced myopathy (SIM) is the commonest reason for discontinuation of statin therapy. The aim of this present meta-analysis is to assess the relationship between glycine amidinotransferase gene (GATM) polymorphism and risk of SIM.

Methods

MEDLINE, EMBASE, Web of Science, and Cochrane Library databases were searched systematically for case-control studies investigating the relationship between GATM polymorphism and SIM. Retrieved articles were carefully reviewed and assessed according to the inclusion criteria. Associations were assessed in pooled data by calculating odds ratio with 95% confidence intervals. Subgroup analysis was performed according to comedications and severity of SIM.

Results

Six studies with 707 cases and 2321 controls were included i

SUBMITTER: Liu M 

PROVIDER: S-EPMC7867530 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature