Predictors of Health Utility in Relapsing-Remitting and Secondary-Progressive Multiple Sclerosis: Implications for Future Economic Models of Disease-Modifying Therapies.

ABSTRACT:

Background

Decision-analytic models used in economic evaluations of disease-modifying therapies for relapsing-remitting multiple sclerosis (RRMS) have characterized disease progression and accrue quality-adjusted life-years from utility values based on the Expanded Disability Status Scale (EDSS), the occurrence of relapses, and progression to secondary-progressive multiple sclerosis (SPMS). The EDSS, used to characterize disability progression, has several limitations. If the EDSS is the only disability measure used in economic evaluations, the long-term clinical and economic implications of disease-modifying therapies may not be properly assessed.

Objective

The objective of this study was to explore if supplementary disability measures including the Timed 25-Foot Walk (T25F

SUBMITTER: Hernandez L 

PROVIDER: S-EPMC7867536 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature