Vitamin D and the hepatitis B vaccine response: a prospective cohort study and a randomized, placebo-controlled oral vitamin D₃ and simulated sunlight supplementation trial in healthy adults.

ABSTRACT:

Purpose

To determine serum 25(OH)D and 1,25(OH)₂D relationship with hepatitis B vaccination (study 1). Then, to investigate the effects on hepatitis B vaccination of achieving vitamin D sufficiency (serum 25(OH)D ≥ 50 nmol/L) by a unique comparison of simulated sunlight and oral vitamin D₃ supplementation in wintertime (study 2).

Methods

Study 1 involved 447 adults. In study 2, 3 days after the initial hepatitis B vaccination, 119 men received either placebo, simulated sunlight (1.3 × standard-erythema dose, 3 × /week for 4 weeks and then 1 × /week for 8 weeks) or oral vitamin D₃ (1000 IU/day for 4 weeks and 400 IU/day for 8 weeks). We measured hepatitis B vaccination efficacy as percentage of responders with anti-hepatitis B surface antigen

SUBMITTER: Kashi DS 

PROVIDER: S-EPMC7867563 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature