A Longitudinal Study of White Matter Development in Relation to Changes in Autism Severity Across Early Childhood.

ABSTRACT:

Background

Cross-sectional diffusion-weighted magnetic resonance imaging studies suggest that young autistic children have alterations in white matter structure that differ from older autistic individuals. However, it is unclear whether these differences result from atypical neurodevelopment or sampling differences between young and older cohorts. Furthermore, the relationship between altered white matter development and longitudinal changes in autism symptoms is unknown.

Methods

Using longitudinal diffusion-weighted magnetic resonance imaging acquired over 2 to 3 time points between the ages of approximately 2.5 to 7.0 years in 125 autistic children and 69 typically developing control participants, we directly tested the hypothesis that autistic individuals have atypical wh

SUBMITTER: Andrews DS 

PROVIDER: S-EPMC7867569 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature